Introduction
Tert-Butyl Diethyl Phosphonoacetate, also known as diethyl (tert-butyl)phosphonoacetate, is a colorless liquid that is used in various fields of study including organic synthesis, pharmaceuticals, and agriculture. In this article, we will discuss the properties, uses, and safety of this chemical compound.
Properties
Tert-butyl diethyl phosphonoacetate has a molecular formula of C10H21O4P and a molecular weight of 246.24 g/mol. It has a melting point of -45°C and a boiling point of 209-211°C. This compound is soluble in organic solvents such as acetone, chloroform, and diethyl ether. It is also slightly soluble in water.
Synthesis
Tert-butyl diethyl phosphonoacetate is synthesized through the reaction of diethyl acetamidomalonate with tert-butyl chloromethylphosphonate in the presence of a base such as triethylamine. This reaction produces the desired compound along with a byproduct, diethyl acetamidoacetate.
Uses
Tert-butyl diethyl phosphonoacetate has a wide range of uses in various fields such as organic synthesis, pharmaceuticals, and agriculture. In organic synthesis, it is used as a building block for the synthesis of other organic compounds. It is also used as a reagent for the preparation of α-aminophosphonic acids, which have antimicrobial and anti-inflammatory properties.
In the pharmaceutical industry, tert-butyl diethyl phosphonoacetate is used for the synthesis of drugs such as phosphonic acid-based protease inhibitors and anticancer agents.
In agriculture, this compound is used as a herbicide and plant growth regulator. It is also used as a surfactant and adjuvant in the formulation of herbicides and pesticides.
Safety
Tert-butyl diethyl phosphonoacetate is a hazardous chemical and should be handled with care. It may cause skin and eye irritation and is harmful if ingested or inhaled. When working with this compound, it is important to wear appropriate personal protective equipment such as gloves, safety glasses, and a respirator. It should also be stored in a cool, dry, and well-ventilated area.
Regulations
Tert-butyl diethyl phosphonoacetate is not listed as a regulated chemical under the Occupational Safety and Health Administration (OSHA) Hazard Communication Standard or the Environmental Protection Agency (EPA) Toxic Substances Control Act Inventory. However, it is important to check local regulations before using or handling this compound.
Disposal
Tert-butyl diethyl phosphonoacetate should be disposed of in accordance with local regulations. It should not be poured down the drain or thrown in the trash. It is recommended to contact a licensed waste disposal company for safe disposal.
Conclusion
Tert-butyl diethyl phosphonoacetate is a versatile compound that has a range of uses in various fields such as organic synthesis, pharmaceuticals, and agriculture. It is important to handle this compound with care and dispose of it properly. By following safety guidelines and regulations, we can ensure that this compound is used safely and responsibly.